Healthy Families program is a community-based, family service initiative committed to improving the health and well-being of women and their families and the economic health of communities. The initiative aims to find best practice solutions for interventions geared towards reducing the incidence of chronic disease and its associated risks among underserved populations. The initiative utilizes evidence-based research findings that provide system thinking implementation strategies to efficiently increase the target population’s access to innovative and culturally appropriate interventions related to nutrition, weight and stress management, thereby improving positive health outcomes. Evaluations of the initiative revealed that the biopsychosocial approach to the promotion of community health interventions improves the effectiveness in which program participants respond to tailored outreach methods. Use of the biopsychosocial approach enhances community involvement through recognition of the unique barriers to lifestyle change experienced by the population being served.